Most of the remaining supply has to be tested for potency.
Clark said that the dispatched drugs "have been tested for potency and purity and will expire in April 2016".
Among the things on the to-do list: certifying labs to test for potency and contamination.
AgraMed would include a bakery to create edible forms of marijuana, a lab to test for potency and contaminants and 100,000 square feet of cultivation space.
After the initial screening, potential "hits" were optimized by medicinal chemistry and tested for potency, specificity, and toxicity.
Texas Department of Criminal Justice spokesman Jason Clark said in a statement last week that drugs dispatched to Virginia "have been tested for potency and purity and will expire in April 2016".
Both FP9 and MVA ME-TRAP were tested for potency in mice prior to the study, and were found to be potent, and slightly more immunogenic than previously used batches of this vaccine (data not shown).
Cell lines were selected with increasing doses of methotrexate, sub-cloned and expanded to a stable clone producing the desired IgM, which was quantitated by ELISA and tested for potency.
Confirmed hits were tested for potency against the pyrophosphatase by modifying the discontinuous coupled colorimetric assay to include 5 mM inorganic pyrophosphate, and compounds showing >15% difference between the pyrophosphatase and coupled assay (Supplementary Table S2) were considered TbUAP hits (12, 0.02% hit rate).
The N-terminal octapeptide N8 and its mutants were also synthesized and tested for their potency as dimerization inhibitors.
