Exact(50)
FTO-SNP rs1121980 rendered the lowest nominal p-value of 1.13×10−7; this SNP was the only SNP that survived correction for multiple testing (corrected p = 0.0494; Table 1).
The multiple testing corrected P-values (Benjamini correction) are reported.
We identified four regions which showed an excess of deletions in controls, but these regions did not remain significant after correction for multiple testing (corrected P > 0.4).
The strongest finding of our study was the association of a nonsynonymous DAOA variant, rs2391191 (Arg30Lys), with visuospatial ability, which remains significant after a conservative Bonferroni correction for multiple testing (corrected p =.005).
In order to detect Gene Ontology (GO) terms that are overrepresented in a gene subsample of interest against all T. castaneum genes as background, we applied Fisher's Exact Test with a multiple testing corrected p-value cutoff of 0.05 and generated a TermLogo similar to [ 12].
We therefore performed an FDR correction using "p.adjust" and provided the list of multiple testing corrected p-values in the additional files (Additional file 1).
Similar(10)
For gene extraction, a multiple-testing corrected t-test (the so-called q-value) is employed.
From a total of 22810 genes represented on the array, genes differentially expressed between experimental samples and controls were detected using two-sample t-tests with a multiple-testing corrected p-value of 0.05 used as the cutoff.
Tukey's test was used to calculate multiple-testing corrected P-values for all pairwise comparisons of plant families.
The method exploits Fisher's Exact Test to produce BH multiple-testing corrected p-values showing whether each GO term that appears in the selected group of genes is over-represented or under-represented.
Multiple-testing corrected p-values [40] and log2 fold changes were extracted for different contrasts.
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