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In this article we introduce an in vitro model for hepato-mediated toxicity testing consisting of a Hepatocyte-Bioreactor connected to a microphysiometer system for monitoring of the extracellular acidification rate (EAR) of cells.
After this examination, all subjects completed the functional testing, consisting of the Functional Movement Screen (FMS) and the Lower Quarter Y Balance Test (YBT-LQ), by an experienced tester who was blinded to the results of the clinical examination.
The first stage is a joint simultaneous testing consisting of two dependent binary tests.
After a training period, testing (consisting of 3 test phases with a total of 25, 13 and 13 trials, respectively) started.
In order to exclude such random effects, permutation testing consisting of 1000 independent random shuffles of the label vector and subsequent determination of BACC was performed.
Samples for ADA testing consisting of approximately 0.12 mL of whole blood were collected from each animal in the PF-05280014, trastuzumab-US, and trastuzumab-EU groups prior to dosing and at one time point/animal after dosing.
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Neuropsychological testing consisted of the Levin Selective Reminding Test (Levin and Wechsler Memory Scale-Revised Editionn (WMS-R).
Priming-induced reinstatement testing consisted of baseline, extinction, and reinstatement phases.
VMC testing consists of 'tracking' trials and of 'tracing' trials.
Testing consisted of three trials per mouse with 15 minutes between trials.
Testing consisted of two phases.
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