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Rat's low levels of Haversian remodeling present little immediate problem when testing agents for their ability to prevent the loss of cancellous bone or rebuild lost cancellous bone.
The most widely used preclinical models for testing agents for the treatment of cancer are xenograft models.
The ethanol-induced ulcer model is useful for studying the efficacy of potential drugs or testing agents that have cytoprotective and/or antioxidant activities [ 7].
Finally, ethidium bromide/acridine orange (EB/AO) fluorescent stain was applied to the cells in the 8-chamber slides after they were incubated with the testing agents for 2 hours to detect live and dead cells.
The shift in trial design toward restricting eligibility criteria rather than testing agents in unselected populations provides a potential opportunity for improved therapy in targeted populations [11], as it has been observed for poly(ADP-ribose) polymerase (PARP) inhibitors [12].
This model has been demonstrated to be suitable for studying the pathophysiology of type 2 diabetes as well as for testing agents for the treatment of type 2 diabetes in several studies [ 16, 33, 34].
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AgentTest is a sublanguage of TTCN-3, aimed at specifying and testing agent-based systems.
Almost all of the tested agents showed a high activity as Topo IIα inhibitors and G-quadruplex stabilizers.
Normal, human T-lymphocytes exhibited less sensitivity to the tested agents.
However, none of the tested agents were approved for clinical application [24].
Being able to generate the neurons which fail in early Alzheimer's and to test agents on them that may promote survival, will be extremely useful.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com