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This is followed by multiple testing adjustments, and mean levels of methylations were compared across phenotype categories while adjusting for the known and computed confounders in the form of PCs.
No multiple testing adjustments were applied.
All the DEGs were obtained after multiple testing adjustments (5% FDR).
Multiple testing adjustments were applied separately to each trait, therefore only controlling for multiple testing within each trait.
Multiple testing adjustments were not performed because the study is in essence replication of previous studies regarding individual SNPs (not discovery) (Table 5).
Transmission disequilibrium test analysis, followed by multiple testing adjustments for all 66 SNPs genotyped, revealed significant genetic association for the SNP rs1641021.
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The Hochberg procedure was used for multiple testing adjustment, and adjusted p < 0.05 was used as the significant criterion.
Stars indicate significant enrichment (One-way ANOVA, P < 0.05; Multiple testing adjustment, FDR) in the different fumigation years.
These multiple testing adjustment procedures are sometimes too strict, and may miss real disease-gene associations in large scale SLAS.
Multiple testing adjustment of the p-values was done according to the methodology of Benjamini and Hochberg [74].
In order to use the closed testing procedure for multiple testing adjustment when comparing three groups, a global test is needed which compares three groups for differences.
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