For multiple testing adjustment, an FDR approach was used [ 19].
Genome wide corrected p-values were calculated using Benjamini-Hochberg multestingesting adjustment procedure.
Further, since multiple tests were applied, Benjamini-Hochberg multestingesting adjustment was used.
The Hochberg procedure was used for multiple testing adjustment, and adjusted p < 0.05 was used as the significant criterion.
Fisher's exact probability, using the FDR (false discovery rate) multiple testing adjustment, was calculated for each GO term (Hosack et al. 2003).
The precise multiple testing adjustment depends on the sensitivity of IBD detection, which depends on the IBD detection method and on the characteristics of the data set, such as the SNP density.
Stars indicate significant enrichment (One-way ANOVA, P < 0.05; Multiple testing adjustment, FDR) in the different fumigation years.
The Benjamini-Hochberg (BH) multiple testing adjustment method, which controls the False Discovery rate, was also performed, using a cut-off of 0.05 [ 93].
Of the 22 miRNAs, 3 miRNAs miR-181a, miRNAs miR-181aR-424—remained significant risk factors (OR > 1.0) or protective factors (OR < 1.0) for ARDS in the validation cohort after multiple testing andustmiR-424 remainedjamini–Hochberg) miR-424 remained
Traditional GWAS analysis [ 39] uses the Fisher exact test and multiple testing adjustment.
Figure 6 presents the observed FDR and power using uncorrected, BH corrected, and BY corrected P-values for the simulations based on model G. Figure 6, top, shows that, except for the AIC-based nonparametric CMST, the observed FDRs were considerably lower than the P-value cutoff, suggesting that multiple testing adjustment is not necessary for the CMST tests.
