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Where applicable, statistical differences between the different groups tested were evaluated using Student's t-test and results were expressed as means ± s.e.m.m
Analyses of significant statistical differences in the mRNA expression obtained for each patient from the four groups tested were evaluated using ANOVA one way and unpaired student t test.
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The ductility of the walls tested was evaluated using the work damage indicator calculated at each loading step from the hysteretic loops.
The reliability of the measure provided by each software tested was evaluated using the intraclass coefficient correlation (ICC) for individual measures, for both baseline and leakage steps [ 11].
ELISA-based tests were evaluated using their respective software/detection platforms.
Statistical tests were evaluated using 5%and10%0% significance.
Correlation coefficient significance tests were evaluated using the cor and cor.test function in R (v.3.1.0).
Statistical tests were evaluated using Microsoft Excel and its data analysis tools.
The frequency of AEs categorised by severity grades and changes in laboratory tests were evaluated using descriptive statistics.
All tests were evaluated using a two-sided hypothesis test with statistical significance interpreted as having a p-value less than or equal to 0.05.
Differences in survival during the IPN challenge test were evaluated using the Mantel-Cox test in GraphPad Prism (version 5.01, GraphPad Software, Inc., San Diego, CA, USA).
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