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However, this theory has not yet been tested using biological data.
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These results support the functional coherence of the proposed Apc-Cdkn1a network and also demonstrate how network-based predictions can be statistically tested using high-throughput biological data.
Categorical data were tested using χ2 analysis.
The biological effect of dap-MWCNTs was tested using rat peritoneal macrophages (PMØ).
We performed another benchmark test using real biological data.
Testing was performed using biological triplicates for each time point.
In order to test real biological data, we used two clonally related datasets that were used to test iHMMune-align (Gaeta et al., 2007) derived from tonsilar IgD class-switched B cells (Zheng et al., 2004).
Data analysis for each treatment was performed using biological triplicates.
There are a few startups using biological material to grow meat in a test tube.
To test the utility of kDDN using real biological data, we applied the kDDN to the public data set GSE7645.
Statistical significance between rapamycin-treated and untreated cultures (Fig. 3; supplementary material Fig. S1) was calculated using one-tailed paired t-tests using data from three biological repeats.
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