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Our findings are crucial because we have tested this intervention for the first time in a resource poor, low income country in terms of the intervention itself and the delivery method.
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Future studies testing this intervention in younger patients may produce different findings.
Conducting field trials to test this intervention is complex and challenging, and researchers have worked hard to generate this body of research evidence.
This cluster randomized controlled trial of the SFP10-14 is one of the first trials to test this intervention outside of the United States.
Testing this intervention in a Canadian primary care setting is crucial to claim its effectiveness and applicability to the Canadian context.
It would, therefore, be important to test this intervention across diverse populations, allow longer follow-up periods and include control sites to avoid bias, before recommending full uptake.
The aim of this phase II study was to determine the feasibility, safety and efficacy of tight glycaemic control with insulin in COPD patients with exacerbations on acute medical wards, towards testing this intervention in a randomised controlled trial.
One recent study combined a mixed multidomain physiotherapy strategy with occupational therapy, testing this intervention in 42 patients with cerebellar degeneration by a randomized controlled study design with delayed-entry of the control group [ 36].
Since timed delivery is such a generic intervention, and there is some evidence from other trials that induction does not increase the incidence of caesarean section, obstetricians and funders may decide that a trial to test this intervention properly is not a priority.
Some centres use cardiac output guided therapy to guide fluid therapy in such patients and it will be important to test this fluid intervention combined with, or compared to such peri-operative strategies.
Of the interventions tested, this association was found to be robust to different measures of malaria incidence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com