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In this work we have tested the potential value of VRK1 and VRK2 protein levels as prognostic markers in low and high-grade astrocytomas, based on the observation that these proteins have an effect on proteins that are known to be affected in the pathogenesis of astrocytomas, such as p53, or EGFR signaling, as well as on other regulators of cell cycle progression.
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Although it remains unclear what will happen after the pilot project is complete, the task force suggested that six months is not enough time to test the potential value of the strategy.
In the present postoperative radiotherapy study, we set out to test the potential value of tumour proliferation parameters to predict the overall treatment results.
If the results are encouraging, then a phase III randomized trial could be conducted to test the potential value of APC in ALI in a large number of patients.
Here we investigated the expression and prognostic impact of Ep-CAM in esophageal SCC to test the potential value of this molecule for antibody based adjuvant therapy in this aggressive cancer.
To test the potential value of targeting the mechanism involving Bcl-2 interaction with IP3Rs in SCLC, we employed BIRD-2, a decoy peptide previously developed in our laboratory and found to induce Ca2+-mediated apoptosis in Bcl-2-positive lymphoid malignancies.
While there is no reliable serum biomarker for the diagnosis and monitoring of patients with gastric cancer, we tested the potential diagnostic and prognostic values of detecting methylation changes in the serum of gastric cancer patients.
Having tested and confirmed the potential value of this approach we would recommend that date inclusion criteria should relate to theoretical justification rather than intervention type in future work.
The investigation of non-murine animal models of AD amyloidosis offers new means of exploring early disease pathophysiology and thereby more rigorously testing the potential translational value of animal models.
Finally, the strong association of WTA with participants' perception of test accuracy points to the potential value of information campaigns to correct misperceptions about the accuracy of HIV testing [66].
The suggested changes also differed among patients, a finding emphasizing the potential value of testing individualized vaccination protocols in clinical trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com