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We then tested the particles as potential drug-delivery vehicles.
The researchers tested the particles in mice that had become obese after being fed a high-fat diet.
The researchers then tested the particles' ability to shut off the gene for a blood clotting protein called Factor VII, which is produced in the liver by cells called hepatocytes.
Working with researchers in the lab of Paula Hammond, the David H. Koch Professor of Engineering and a member of MIT's Koch Institute for Integrative Cancer Research, the team tested the particles against ovarian cancer cells grown in the lab.
As the figures show it and for each parameter set tested, the particles simulation framework is consistent with the predicted behavior: a curvilinear Michaelian-type curve with the correct affinity κ - using the simulation parameters S r, S t, p1 and p-1).
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In the JACS paper, Johnson and colleagues demonstrated that the triple-threat nanoparticles could kill ovarian cancer cells more effectively than particles carrying only one or two drugs, and they have begun testing the particles against tumors in animals.
They are now testing the particles in a more complex mouse model of triple-negative breast cancer, and they are also working on adapting the particles to treat ovarian and lung cancers.
The PEG molecules are topped with a peptide sequence that binds to activated platelets, helping them stick together to form clots. Next steps: Researchers plan to test the particles in larger animals, whose circulatory systems more closely approximate those of humans.
In the drinking water tests the particles are exposed to diluted human saliva for only a very short period of time (30 s).
The aim of this study was to fabricate MWCNTs and further to test the particles as a part of carbon composite electrodes with commercial carbon particles on detection of nucleic acids.
Testing the particles on animals is less effective, she said, because black lung-like symptoms may take an animal's entire life to develop.
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