Based on this hypothesis, for each significant miRNA we tested the leading-edge subset of genes for functional enrichment using curated annotation databases, such as Gene Ontology [ 39], KEGG [ 40], BioCarta [ 41], Reactome [ 42] and ACSN [ 43].
A novel aspect of our study is that we focused on the feasibility of HER2 testing in CTCs from a heavily pretreated metastatic breast cancer patient population and comparison tested the two leading CTC platforms, CellSearch® and CTC-Chip.
She is waiting to enter a new type of Alzheimer's drug study that will, in the boldest effort yet, test the leading hypothesis about how to slow or stop this terrifying brain disease.
After extensive modifications and tests, the leading new scaffolds might become the next generation of HIV protease inhibitors possessing novel chemical structures and alternative binding patterns to HIV protease.
For the reciprocal test, the leading edge gene (GLEG) method trained on the Wang data set achieved 68.97% accuracy in classifying metastasis in van de Vijver et al. [ 6], while the reciprocal accuracy (training using van de Vijver and testing on Wang data) yielded 65.83% accuracy (as before these accuracies are reported on data sets balanced between the two phenotypes).
Opie and his colleagues set about testing the three leading hypotheses in primates using a powerful method called Bayesian statistics.
(2) Is it possible to test the principles leading to the theorem: the Sum Rule and Product Rule, FUNC, or NC? (3) Is it possible to test the theorem itself?
From its endorsement by the WHO in December 2010 to the end of June 2012, 1.1 million tests had been purchased by 67 low- and middle-income countries; South Africa (37% of purchased tests) is the leading adopter.
Samoa looked one of the few representatives of the so-called 'next tier' of countries still able to provide a decent test for the leading nations.
At the very least, the drug studies will be the first real test of the leading theory of Alzheimer's, which blames amyloid for setting off a chain of events that ultimately ruin the brain.
