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Thus, the tested target genes show a distinctive binding pattern of p53 phosphorylated at S46 upon Etoposide treatment which in some cases is also accompanied by a respective expression change.
For all tested target sites the binding of p53 phosphorylated at S46 is higher upon Etoposide treatment than upon Actinomycin D treatment (Figure 6A) while the difference of binding of p53 phosphorylated at S15 is much smaller upon the two treatments (Figure S5).
The tested target genes were MLH1 and FANCD2.
However, all of these mutations compromised the transcriptional activation of a tested target gene.
So far, Hsp90 has been the most widely tested target for cancer therapy.
Experiment 1 tested flanker substitution; Experiment 2 also tested target substitution.
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The average AUC among all the tested targets is 0.61.
Additional file 4: Analysis of the changes of accuracy for different steps for all tested targets.
In general, PharmDock provides an AUC above random for 22 out of the 29 tested targets.
Despite most of the tested targets were small-sized dielectrics, approximately full detection performance is obtained in this soil type.
A variety of therapeutic agents are being tested, targeting HDAC's deacetylase activity.
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