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The RTL algorithm is based on the analysis of the RTL prognostic parameter, which is designed in such a way that it has a negative value if, in comparison with long-term background, there is a deficiency of events in the time space vicinity of the tested point.
Where possible we tested point mutations of the genes in question.
If the distance d a, H) of the tested point a from the resulting hyperplane H lies between the hyperplane and fmax, then the tested point a is defined as similar to the training set TS.
In analyses in which we additionally excluded individuals with addresses outside the region in which the model was originally developed and tested, point estimates were stronger but did not meet statistical significance because of the reduction in sample size.
To explore which residues were critical for ubiquitinPhospho-Ser65 function towards Parkin, we tested point mutants of all the putative Parkin pocket residues in a PINK1 kinase assay in the presence of ubiquitinPhospho-Ser65 (Fig 2B).
The mean deviation between the correlated and the tested point found to be 2.94%.
Similar(53)
At most, but not all, of the tested points, the fit was bad.
It was not to test point specificity or other hypothesis.
Testing points were selected in random order.
Tests point to arsenic, and rumors are rife.
All tests point to a strange form of gravity we call dark energy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com