Hv.5064, the candidate for miR1137 coding sequence, has been tested for modifications of pre-miRNA structure due to a base substitution in position 13 (C/G, table 6, figure 3).
Likelihood ratio tests were used to test for modification of the effects by ethnicity.
We also test for modification of the genetic effect by smoking by testing the contrast between the estimated parameters of model I for never or light smokers versus for moderate or heavy smokers.
Because of the small number of never or light smokers beyond cases no significance (p = 0.9012) was achieved when testing for modification or the genetic effect by SEL groups.
Because of the small number of never or light smokers beyond cases no significance (p = 0.1770) was achieved when testing for modification or the effect of gPS by SEL groups.
We included interaction terms between estimated glomerular filtration rate and treatment strategy in regression models to test for modification of the treatment effect by baseline estimated glomerular filtration rate.
In an attempt to explain differences in release rates of immature miRNAs, we sequenced some pre-miRNAs to test for modifications including RNA editing [66], yet found none (Table S7).
We tested for effect modification by age group (comparing 30- to 39-year and 40- to 49-year age groups) and effect modification by sex using Poisson regression interaction terms with two-tailed tests.
