Each pool was tested for activity on mechanically activated currents expressed by DRG neurons.
Using KINOMEscan (Ambit Biosciences, San Diego, CA, USA), Nec-1 (10 μM) was tested for activity against 485 kinases and activated mutant kinases.
Unfortunately, not many actively-used antiretroviral agents have been tested for activity against MLV, with the exception of ZDV, which effectively suppresses MLV [12], and was recently demonstrated to be effective against XMRV as well [13].
ICA-105665 was the first activator of neuronal Kv7 potassium channels tested for activity in the photosensitive epilepsy model in humans.
Compounds not detected as "active" in the first stage are tested for activity at the lowest tested concentration in the second stage.
We have also detected potential 'quick wins' through the identification of targets for repurposing known drugs or active chemical tool compounds that can be tested for activity in cancer models.
After the reaction is completed, the chambers are individually tested for activity.
These monolithic biocatalysts were tested for activity and stability and compared to similarly prepared biocatalysts employing classical cordierite ceramic monoliths.
Platinum catalysts (1.5 wt.%) containing AlSBA-15 obtained with various aluminium precursors were tested for activity in 1-methylnaphthalene hydrogenation.
Based on the essential structural requirements predicted by the QSAR models, some analogues were designed, synthesized and tested for activity.
The regenerated catalyst was observed to outperform the fresh formulation when tested for activity in the conversion of lipids to fuel-like hydrocarbons.
