Sixty seven genes were identified as containing testable response elements, and chromatin immunoprecipitation was performed on these putative gene targets, as described previously [29], using embryonic day 18.5 and postnatal day 30.5 retinas from B6 and rd7 mice.
(Such hypotheses may include empirical elements that are testable, of course: the hypothesis that God created the universe about 6,000 years ago, for example, is testable, has been tested, and turns out to be false. But the hypothesis failed only with respect to the age of the universe; the broader hypothesis that God created the universe is unaffected by the failure of the narrower hypothesis).
Developing and ranking adverse effect scenarios and formulating testable risk hypotheses are key elements of our approach.
Thus, our work suggests a testable hypothesis that important regulatory elements reside in these differential regions.
Continued progress will require renewed focus on elements of the scientific method: testable predictions, crucial experiments and falsification of hypotheses (Popper K. All life is problem-solving, Routledge, London, 1999).
In every case, however, these elements must yield consequences that are testable, either by themselves or in conjunction with empirically derived notions (PD 47).
Although the elements of PIRO should be readily testable in clinical and basic research in sepsis, this approach has yet to be fully evaluated as a novel clinical tool for patient evaluation.
The results presented here demonstrate the concept that combining SSH methodology with PAINT-guided transcriptional regulatory element analysis permitted the generation of testable hypotheses regarding differences between mucosa and detrusor regulatory networks in health and disease states.
On the other hand, in order to validate the proposed systems approach one may deduce testable hypotheses which focus on isolated aspects and analyze few genetic elements.
Testable hypotheses which focus on isolated aspects and analyze few genetic elements have been derived from the systems approach and an algorithm has been proposed which may be used to modify somatic cancer evolution for therapeutic purposes in individual patients.
