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The sub-optimal performance of each test under study prompted us to evaluate their combination in parallel.
Obviously, our clinical diagnosis comprises the test under study which may introduce bias.
The advantage of this method is that it allows clinicians to estimate how changing thresholds will alter the diagnostic utility of the test under study.
This allows us to determine both PPV and NPV of the index test under study, as well as its sensitivity and specificity.
For future analyses the most appropriate model will depend on the hypothesis to be tested, the cognitive test under study and the study design.
Limitations in the design and conduct of the study may lead to overestimation of the accuracy of the test under study [ 5, 6].
Similar(47)
4 34 39 The extent of follow-up failure was reported as a proportion of inpatients 4 20 33 34 or of tests under study.
Published guidelines recommend that pilot studies be undertaken to allow trial protocols to be tested under study conditions prior to evaluation in a full randomised controlled trial.
The test specimens under study were made of an ordinary concrete substrate and sand concrete (repair material).
The safety of herbal medicine has continually been questioned due to reported illness and fatality of the test animals under study [4].
In this regard, drawing conclusions without considering the risk of bias in included studies may lead to unwarranted optimism about the value of the test(s) under study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com