Indeed patDp/+ mice displayed these signs in the cued and contextual conditioning fear test, the elevated plus maze test, and the Porsolt forced swim test.
Geller-Seifter test), the elevated plus maze (EPM), and the open field test (OT) and thus differs from paradigms that elicit fear (when threat is acute) [ 1, 12] or panic (when threat is immiment) [ 1, 13].
Repeated exposure to another commonly used behavioural test, the elevated maze, has been reported to result in a decrease in total locomotion and a decrease in the amount of time spent on aversive open sections of the maze (e.g. Cook et al., 2002; Dawson et al., 1994; Rodgers et al., 1996).
To test if the elevated p53 expression correlates with the transcription of p53 target genes, the expression of p21, a canonical p53 target, and PUMA, a pro-apoptotic gene of which the transcription depends on p53 and NF-κB, were analyzed.
Twenty-two mice of each genotype were used for general health and neurological screens, neuromuscular examinations, light/dark transition test, open field test, elevated plus maze test, hotplate test, rotarod test, marble burying test, prepulse inhibition test, Y-maze test, tail suspension test, and contextual and cued fear conditioning test in the described order.
MAK (0.3 or 1 g/kg), imipramine (10 mg/kg) as a positive control, or distilled water was administered orally 60 min before the forced swimming test, open-field test, elevated plus-maze test, or contextual fear-conditioning test.
Leea macrophylla root methanol extract (LM) was assessed by open field test, hole cross test, elevated plus maze test and thiopental sodium induced sleeping time test for screening neuropharmacological effect on Wistar albino rats using the LM at 100 & 200 mg/kg body weight.
To investigate neuropharmacological activity open field test, hole cross test, elevated plus maze (EPM) test and thiopental sodium-induced sleeping time tests were performed.
His investigations revealed highly positive Mantoux test, negative QuantiFERON test, elevated serum ACE, and HRCT of chest showing features of sarcoidosis.
The mice were also tested in the Elevated Plus maze, a standard test for fear and anxiety.
Previously, we have characterized the consomic strains in three behavioral models of anxiety, the open-field test, elevated plus maze test (EP), and light/dark test, and factor analysis identified five factors that underlie anxiety-like behavior (locomotor activity, thigmotaxis, EP open-arm exploration, risk assessment, and autonomic emotionality; Takahashi et al. 2008).
