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If the principle of superposition holds, then the effects of these two periods should be combined when constructing a histogram to test periodicity.
Not all these models test periodicity, nor are they all testable with our data.
This proportion depended on the assumed doubling time and the test periodicity in the screening interval (Table 3).
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There are 2 statistical tests for testing the periodicity of the series: The Fisher's Kappa test and the Bartlett's Kolmogorov-Smirnov (BKS) test.
All expression profiles were tested for periodicity by autocorrelation test and sorted in order of decreasing correlation between an early time and a second time 24 hours later.
In all cases the algorithm for detection of signal is based on a test for periodicity in a series of measurements rather than static comparison of signal and background noise levels.
The statistical method proposed by Tsai et al. may avoid this problem, since it is not based on the test of periodicity [ 13].
As before, we restricted our choice to gene with circadian BMAL1 binding with a FDR<0.05, based on a Fisher test for periodicity as suggested by the authors of the study.
There are a few available tests for periodicity; we suggest Pt-test [14], specifically developed for short time series with low sampling rate, typical for gene expression profiles.
A window W moving along the stream is tested for periodicity using one of the previously described tests.
Tests for periodicity applied in a straightforward way and testing each expression profile independently report considerable numbers of periodic transcripts (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com