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The patients were allocated into two groups - group A (38 patients with successful 2-hour spontaneous breathing through a T-circuit) and group B (seven patients with unsuccessful 2-hour test of weaning with a T-circuit system).
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In studies of f/VT as a weaning predictor, the pre-test probability of weaning success exceeded 75% in more than half of the studies [ 7].
Taking into account the likelihood ratios, we have also calculated the post-test probability of weaning success for different pretest probabilities (Table 2).
In such cases, most physicians would not attempt to wean the patient when the post-test probability of success is lower than 20%, but it is also possible that some physicians may decide to attempt weaning when the post-test probability of weaning success is higher than 30%.
Moreover, the usefulness of a f/VT ratio value higher than 100 to decide on readiness for weaning remains controversial when used in populations of patients with pretest probabilities of 50-70%, who may have post-test probabilities of weaning success that range from 5to46%6%.
For optimal results with a screening test such as f/VT, it must be conducted at a time when a negative result is far more likely than a positive one – when the pre-test probability of weaning success will be much less than 50%.
The Bayes' theorem was used to assess the probability of each test of predicting weaning.
The post-test probability is the probability of weaning success, taking into account the results (positive or negative) of a diagnostic test such as the measurement of the f/VT ratio.
The IWI presented the highest probability of weaning success when the test was positive (0.99) and the lowest probability of weaning success when the test was negative (0.14).
Moreover, IWI presented the highest probability of weaning success when the test is positive (0.99) and the lowest probability of weaning success when the test is negative (0.14).
Further data are required to test the effect of loxapine on the duration of weaning.
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