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Presence/absence scores for each tag were used in a binomial test of segregation versus an independent framework map.
To determine how many of the remaining presence/absence GBS tags could be genetically mapped in maize, the binomial test of segregation was repeated versus this high density framework map, with a threshold of p<0.0001.
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Probabilities from Chi square tests of segregation ratios against expected ratios of ordered markers were derived [ 76].
Thus an enormous amount of work, likely involving larger scale mutation screening efforts to gain more analytic precision, tests of segregation to examine penetrance and tumor spectrum, and perhaps development of functional assays to aid evaluation of rare missense substitutions, remains to be performed on with MRE11A, RAD50, and NBN.
DNA was unavailable from either parent of case 6 to test for segregation of the p.P525L and p.Y374X mutations, however, clinical records describe the mother of case 6 to be a young onset ALS patient in which the early onset and aggressive course suggests the disease to be due to the FUS mutation.> -wrap-foot> Mutatidentifiedinied in the gene encoding FUS (Refseq: NM_004960).
Samples were not available from other family members to test for segregation of these GRN variants.
Unfortunately for reasons of clinical governance we were not in a position to evaluate tumour blocks from relatives to test for segregation of alleles.
When no QTL was detected for a chromosome by trait combination, the hypothesis of no QTL on the chromosome (H0) was compared to the H2 hypothesis to test for segregation of two antagonistic QTL.
1 number of genotypes, accessions, species, subgroups belonging to the phylogenetic groups as classified by Hawkes [ 2] 2 number of genotypes with resistance data obtained in various assays 3 number of populations tested for segregation of resistance to late blight.
A total of 178 parents were tested for segregation of the QTL, identifying 72 QTL-heterozygous parents.
Twelve independent tetrads were tested for segregation of high GPXH-ARS expression in each mutant.
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