A series of "proof of principle" experiments has passed an independent audit from European Space Agency (Esa) experts, and Mr Osborne himself has inspected the test rig on the Culham science park in Oxfordshire.
In addition, a series of 'test of principle' experiments were performed to assay the ability of Conk-S1 to block channels expressed from cRNA encoding the following dimeric constructs: homomeric Kv1.2/1.2, and heteromeric forms in the two possible orders of linkage, Kv1.2/1.7 and Kv1.7/1.2.
The proof-of principle experiment of the BPL method has been described in detail [ 18].
Since solid tumors often contain hypoxic regions, we performed proof-of-principle experiments testing whether this transgenic mouse model may be used as a universal platform for non-invasive imaging analysis of spontaneous solid tumors.
Finally, proof-of-principle experiments testing the therapeutic benefit of AE inactivation are missing.
This paper describes results from proof-of-principle experiments designed to test the multi-isotope process (MIP) monitor, a novel approach to monitoring and safeguarding reprocessing facilities.
We present two proof-of-principle experiments to validate our approach.
The effectiveness of several sorbents in capturing mercury released from fractured CFLs was tested in a proof-of-principle experiment using the flow system discussed above.
As the goal of the library is to identify biologically relevant functions of miRNAs, we performed a proof-of-principle experiment by testing the well-documented effects of let-7a [ 49- 51] as an inhibitor of cell proliferation and miR-372 [ 38] as a stimulator in five cell lines.
As a proof-of-principle experiment, we tested the functional effects of the Wnt/β-catenin signalling in CRPC using LNCaP-AI cells [27] by WST-1 proliferation assays in the presence of a well-characterised Wnt/β-catenin signalling inhibitor [13] (Fig. 3A).
If a grant aims to test a new principle, then a proof-of-principle experiment must be provided.
