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As a test of principle, depletion of SIK3 enhanced mitotic arrest and cell death induced by classic spindle poisons, including nocodazole and Taxol.
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To test proof of principle, we then tested the ability of RANTES and IP-10 conditioned CFP10-DCs to clear an established infection in mice.
Placebo-controlled N-of-1 randomized design, such as the one used here, provides a useful means to test proof-of-principle for potential new therapies.
The current study was designed to test " proof-of-principle" with respect to whether repeated CNT is an intervention capable of reducing naturally occurring depressive symptoms in a dysphoric sample.
Nevertheless, a randomized controlled trial testing proof of principle for an attentive eating intervention on weight loss is warranted, so that it will be possible to examine any potential benefits to weight loss over a longer period of time.
In response to queries on the retrograde effort, the military's Transportation Command said the recent shipments through Pakistani border crossings were a test — "proofs of principle shipments" — to gauge whether the routes can be dependable.
In order to test proof of principle, we next investigated the role of L-type and R-type VGCC in regulating M. tuberculosis infection in mice.
There were several areas of discourse, however, that failed the test of the principle but that nevertheless were impossible to rule out in this fashion.
The Gleevec case is the first big test of that principle.
The construction of the mosque, Mayor Michael Bloomberg told New Yorkers, is as important a test of the principle of religious freedom "as we may see in our lifetimes".
The test of that principle has been at the center of the continuing trans-Atlantic trade fight over hormones in American beef.
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