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The total number of sample points after preprocessing is 4560, which are then normalized to the interval [0, 1] and divided into three groups: 1) 1 to 500 points are set for modeling initialization to accumulate the sample dictionary and steady the modeling effects; 2) 501 to 2000 are for the cross validation test of parameters; 3) The remaining 2001 to 4560 points are the accuracy test samples.
So, we carried out a Mann–Whitney U test of parameters of the network to compare genes having extreme iHS values (and thus putative signal of positive selection) and genes with no extreme results.
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We performed the Wald χ test of parameter equalities for gender group differences in the structural regression paths.
Although the path from paternal symptoms to sons' symptoms was not significant, this path was not significantly different for daughters and sons (Wald test of parameter constraints (1) = 0.159, p = .69).69
If the model can be estimated, focus turns to evaluations of the degree to which the model accounts for the data (i.e., fit), and estimates and tests of parameters in the model.
§From Wald tests of parameters of logistic regression model.
In addition to these tests of parameters, we also investigated two special cases, i.e. all-hot and all-cold.
Questions discussed were: (1) model improvement (optimization of parameters and use of scaling factors), (2) sensitivity testing of parameters, and (3) methodology to define inputs.
Thus, an important caveat for all synthetic gene network studies is to consider extensive measurement and testing of parameters and variables; unexpected behaviours can arise even in very simple networks.
The first type of evidence is based on tests of parameter instability over the period 1999Q1 2015Q4.
Looking beyond the usual measures of fit and adequacy, residual analysis revealed nothing out of the ordinary and tests of parameter coefficients significance all looked satisfactory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com