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Can a definition be proposed that meets the test of neutrality (that is, does not prejudge any policy question)?
Selection pressure was examined with the test of neutrality of Ewens-Watterson [91], [92].
Therefore, it is convenient to use an alternative test of neutrality.
To test for genetic signatures of recent population size changes, Fu's test of neutrality [Fs, 42], Tajima's D [77] and Fu and Li's F and DF test statistics [78] were compared among regions and subgroups.
Using the HapMap and Perlegen polymorphism data that map to a stringent set of putative binding sites in human proximal promoters, we apply the Derived Allele Frequency distribution test of neutrality to provide evidence that many human-specific and primate-specific binding sites are likely evolving under positive selection.
Population history was also inferred using Fu's FS test of neutrality [ 31] as implemented in ARLEQUIN.
Similar(19)
For all tests of neutrality, coalescent neutral simulations were run under different demographic models to assess the significance of the resequencing data.
Codon-based z-test of neutrality showed that observed mutations are significantly neutral only within concatenated Groups I and III.
Tests of neutrality using stringent significance thresholds, performed under the standard neutral model, revealed one to seven outlier loci for each species.
We applied four different tests of neutrality to identify the genomic regions that deviate from neutral expectations potentially associated with fiber and linseed divergent selection.
Correlative studies have a central role in tests of neutrality and novel analytical techniques are continuously developed to enable the fit of neutral and non-neutral models to observational data [16] [19].
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