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For starch in polar organic media, a visual test of dissolution was shown to be invalid: it is possible to obtain a clear and transparent starch suspension from which nothing precipitates upon centrifugation but within which starch is not completely dissolved [ 35].
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Prednisone 50 mg tablets, normally used for control tests of dissolution baths, were followed for 3 h.
The test for content expresses the amount of active ingredient as a percentage of the label claim, and the test for dissolution determines the amount of active ingredient released and available for absorption (13 ).
The test for content assesses the amount of active ingredient measured in a formulation, expressed as a percentage of the label claim; the test for dissolution determines the amount of active ingredient that is released and available for absorption [4].
When the drug availability is spontaneous (e.g., inhalation), or when the drug release rate is preprogrammed (e.g., implants), statistical tests of the dissolution profile similarity may not adequately characterize in vivo product performance.
None of our plankton-tow Mg/Ca data shows any evidence of test dissolution in the water column.
An example of application of experimental design methodologies to the set up of dissolution test conditions for a new ketoprofen oral extended-release dosage form is presented.
The proposed mathematical model is found to be robust and accurate for optimization of dissolution test conditions for site-specific release isoniazid pellets.
Evaluation of dissolution test results at 30 min using an internal DPA calibrator tablet NCDA 2 (10 mg prednisone) indicates that the main contribution to the total variance, approximately 70%, is due to the sample tablets, approximately 25% is from the apparatus and approximately 5% is due to the operators.
After 1 and 4 hours of dissolution test, the sustained release matrix released 45% and 48% of its drug content, respectively.
It is clear that F2 matrix exhibited the highest drug release as 32.89% of IDM was released after 2 hours of dissolution test in pH 6.8.
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