In the Step Vaccine Study, a phase II test-of-concept study trial of the Merck HIV-1 gag/pol/nef vaccine, men who have sex with men (MSM) with previous exposure to HAdV-5 through natural infection appear to have had at least transiently increased risk of acquiring HIV after vaccination [15], [20].
Both temperatures tested in the proof of concept study reduced the amount of VRE after disinfection below the detection limit of the methodology for environmental samples (Table 1).
This was a 'proof of concept' study designed to test a novel analytical method and set hypotheses about pathoanatomical pathways of vertebral segment degeneration.
A subset of library compounds was tested against a panel of 117 protein kinases as proof of concept study.
For the RELAX-AHF-1 study, two primary endpoints were chosen from among those tested in the proof-of-concept study: moderately or markedly better dyspnea reported on the Likert scale at 6, 12, and 24 h; and the area under the change in dyspnea visual analogue scale score from baseline to day 5.
Our aim is to describe an early neurocognitive stimulation intervention based on virtual reality for patients who are critically ill and to present the results of a proof-of-concept study testing the feasibility, safety, and suitability of this intervention.
This paper reports the results of a proof-of-concept study testing the efficacy of a novel self-examination intimate swab designed for recovering DNA following unprotected sexual intercourse.
Nominal observed P values are reported without adjustment for multiple testing in this small proof-of-concept study.
The present proof-of-concept study tests a much simpler system of taking thermal images of groups of animals on a regular and frequent basis for the purpose of detecting febrile responses.
In this pilot, proof-of-concept study we tested the ability of a novel test, DRIN, in predicting microalbuminuria onset and GFR decline in a cohort of newly diagnosed, drug-naive patients with hypertension or T2DM.
We designed this retrospective proof-of-concept study to test our primary hypothesis.
