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These 'global' enrichment statistics can be categorical, such as Fisher's Exact Test of category membership versus statistical significance of the genes, thus providing a resampling version of common genelist enrichment tests (Khatri and Draghici, 2005).
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Appropriate adjustments – Scheffé adjustments for pairwise differences in ANOVA, Bonferroni adjustments in z-tests of category proportions and Mann–Whitney U tests – were made to account for multiple testing when carrying out pairwise comparisons.
To determine whether a functional category was significantly enriched in one gene set with respect to another, we performed a two-sided Fisher exact test of this category against the combination of every other category.
This Sporting Life has stood the test of "classic" category; at the time the Guardian staffer and rugby league buff Geoffrey Moorhouse hailed the novel as "unique", adding that "an interest in rugby league is by no means necessary to appreciate this story, any more than a fascination with whaling has ever been vital to an enjoyment of Moby Dick".
Finally, the DEGs versus length function was incorporated into the statistical test of each category's significance.
We choose total numbers of fictitious data sets of 50, 100 and 200, and we assume pre-test probabilities of category "disease" [P(D)] increasing from 0.10 to 0.90 in steps of 0.10.
For practical reasons (eg, club level; no technical or physiological measurements available), the Cooper 12 min Run Test could be useful, 30 although tests of this category are characterised by a lower reproducibility because of tactical and motivational aspects.
Response intensities of inoculation groups were analysed with the Mann–Whitney U-test, frequencies of categories of parameters were compared using Pearson's χ-test.
All tests of functional category enrichment for particular gene sets were performed using the Gene Ontology Biological Process category.
We performed unsupervised clustering of carcinoma cases according to their protein expression profiles, and we tested distribution of categories of clinical and molecular variables in these groups.
The models tested of each category are mentioned in Table 1.
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