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Simulation of the imbibition cell test is complicated due to the following reasons: Since there are no wells to cause flow, the convective fluxes are very small and lead to severe variation in properties between rock and non-rock gridblocks.
This test is complicated by the availability of matched transcriptomes.
This test is complicated by relatively high false positive and false negative rates, 8 9 10 so it is almost always followed up by the "gold standard" test of 24 hour urine collection.
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Risk equivalence testing is complicated by the binary nature of the outcome, its low frequency, and by the absence of commonly defined equivalence limits for differences or ratios.
Testing is complicated by the indirect nature of the observations used to reconstruct environment and behavior and by the cumulative nature of the archaeological record.
Tay-Sachs testing is complicated in that if one is tested only for mutations most commonly found among individuals of Ashkenazi Jewish background, carriers could be missed, even within the Jewish population.
Educating people about carrier testing is complicated.
Testing is complicated by discontinuity of care after delivery and mothers underestimating their diabetes risk and stress to adapt to the challenge of caring for a young baby.
Furthermore, interpretation of the tests is complicated by adaptive changes in renal function which occur with aging and in response to other disease processes.
Specific diagnosis of WNV infections using current serological testing is complicated by the high degree of cross-reactivity between antibodies against other clinically relevant flaviviruses, including dengue, tick-borne encephalitis (TBEV), Japanese encephalitis (JEV), and yellow fever (YFV) viruses.
Formal hypothesis testing is complicated by the fact that the disease model we are seeking to evaluate is only an approximation to the actual disease; consequently testing the null hypothesis of no difference between the validation study observation and model predictions makes little sense.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com