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Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct.
A one-sided test is appropriate to test for superiority.
Finally, a test for superiority of insulin glargine vs placebo was performed.
It should be noted that some trials (e.g., CAROLINA [ 13)]) are designed to test for noninferiority first and, if successful, subsequently test for superiority.
Many seem to assume that lack of significant differences between active interventions demonstrates equivalence, which is inappropriate in trials designed to test for superiority that are neither designed nor powered to demonstrate non-inferiority.
This project aims to test for superiority of operative treatment versus non-operative treatment for displaced olecranon fractures in the elderly, by comparing pain and function in the affected limb up to one year after the injury.
Similar(53)
We plan a group sequential design with 2 interim analyses using a survival model approach for "time-to-degeneration" and a test-for-superiority approach.
All other endpoints were tested for superiority.
*P values from two sided tests for superiority.
*P values from two sided tests for superiority where given.
The primary outcome was tested for non-inferiority whereas the remaining outcomes were tested for superiority.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com