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The Mantel-Haenszel test for summary statistics was used to evaluate possible confounding (27); interaction was assumed when the test for heterogeneity between the OR for different strata was significant (p<0.05).
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We then tested our data using lineage-site Model A and identified positive selection in 24/26 placental mammals across 48/52 of the gene families tested, for summary of results see Figure 2 and Additional files 2 and 3.
Construct validity was measured using principal component analysis, and the Pearson Correlation test for item-summary score correlation and inter-instrument correlations.
Therefore, we did not consider informativeness, and we automatically proceeded to quantitative robustness testing for the summary diagnostic odds ratio (DOR).
The two groups of parents were compared using the t-test for the summary score and chi-square and Mann-Whitney U tests for categorical variables and ordinal variables.
To test reliability, the internal consistency for summary measures was estimated using Cronbach's alpha coefficient and alpha equal to or greater than 0.70 was considered satisfactory [ 25].
To test reliability, the internal consistency for summary measures was estimated using Cronbachs' alpha coefficient and alpha equal to or greater than 0.70 was considered satisfactory [ 30].
None of the pairs of loci showed significant linkage disequilibrium (all P > 0.4, exact test for genotypic disequilibrium), and summary statistics for all 10 loci are given in Table S1.
Table 2 summarises the numbers of participants completing each test and summary measures for these tests.
Neuropsychological test score summary measures for fallers and non-fallers are presented in Table 2. *Pearson Chi-square test **Wilcoxon rank-sum test To determine the underlying cognitive factors that may account for an increased likelihood of falling, univariate analyses compared global and domain-specific cognitive z-scores between fallers and non-fallers.
The five cox2-3 handothees and the unique rbcL-S haplotype were used as markers for summary statistics, neutrality tests Tajima's D and Fu's Fs and for median joining network analyses.
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