1Kruskal-Wallis test for ordered categories.
Agreement between the two psychologists was assessed with a weighted κ reliability test for ordered data.
Comparisons were done using χ test (chi-square test) for proportions and Mann Whitney test for ordered or continuous variables.
P values for trend analysis were calculated using a Jonckheere-Terpstra test which is a nonparametric test for ordered differences among classes.
Evaluation of the association between PODXL expression and clinicopathological parameters was done by the Fisher exact-test or the linear-by-linear association test for ordered parameters.
We used Page's L test for ordered alternatives [42] to test the statistical significance of differences between routes generated in three or more experimental conditions.
The influence of radiographic grade to the serum levels of the molecular markers was tested using the non-parametric Jonckheere-Terpstra test for ordered groups.
Evaluation of the association between PODXL expression and clinicopathological parameters was done with the Fisher exact-test or linear-by-linear association test for ordered parameters.
The Jonckheere-Terpstra test for ordered alternatives was used to identify trends in patient identified single task difficulty (Q1) and importance scores (Q2) across responses to Q3.
Parametric tests (paired t-test) will be used if the distributions are normal and non-parametric test (McNemar test and Wilcoxon signed ranks test) for ordered or continuous data.
