Comparisons between tumour samples and patient-matched normal mucosa were made using the Wilcoxon test for matched pairs.
Differences in distributions across groups were tested using Wilcoxon signed-rank test for matched data.
Proportions were compared using the Fisher exact test for independent samples and the McNemar chi-square test for matched pairs.
McNemar's test for matched pairs was used to compare admission and recidivism rates at EDCC and non-EDCC hospitals.
Differences in categorical variables were analyzed using the Chi-square or the Fisher exact test or the McNemar test for matched patients, as appropriate.
Since data were not normally distributed, a Wilcoxon signed-rank test for matched pairs was applied to test for differences in SUVMEAN between ROIs in PETDIXON and PETINPAINTED; p < 0.05 was considered to be statistically significant.
In addition, we compared the soil characteristics between the two forest types using paired t test for matched pairs (n = 3) for both top and deep soils.
Non-parametric tests were used including Mann-Whitney tests for comparing independent variables, Wilcoxon rank t-tests for paired samples, unpaired t tests for replicate experiments, and Spearman's rank test for matched correlations.
Proportions were compared using the χ2 test and the McNemar test for matched-pair data was used to analyse the directional selection of mutations from day 0 to day 14.
We further compared the percentage of TUNEL-positive nuclei between the four groups using Friedman test for matched non-parametric data and confirmed the difference between the control group and the vitamin group either at normoxia or HR.
