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Within-group differences were tested using Wilcoxon Signed Rank Test, and between-group differences by means of Mann–Whitney U test for Baseline and in change scores between Baseline to Post 2 and Post 5 months, respectively.
A control experiment with no rat present was performed to test for baseline effects of cortagine in the exposure setup.
We did not test for baseline differences between the intervention and control group.
Chi-square tests and student t-test were employed to test for baseline differences in demographic items.
The same tests were used to test for baseline differences between participants who achieved a remission and those who did not.
We will report baseline demographic and clinical characteristics for each study condition and test for baseline equivalence using parametric and non-parametric test as appropriate.
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We used non parametric Wilcoxon tests and Fisher exact tests for baseline univariate comparisons across groups, p-value equal or below 0.05 were considered statistical significant.
Strengths of this research include using randomized designs (62.9%), testing for baseline group equivalence (84.5%), and monitoring treatment, which rose significantly from being used in 48.1 64.4% of projects over time.
Statistical analyses utilized Fisher's exact tests for baseline BMI group comparisons for categorical variables and Kruskal-Wallis tests for continuous measurements.
In both cases, the naïve animals used for controls were also tested for baseline behavior but did not receive paw incision surgery.
The untreated animals that provided tissue for the ECB concentration and CB1 and CB2 receptor expression and cellular localization studies were tested for baseline values, received paw incision surgery and were tested before tissue collection on postoperative days 1, 3, 9 or 15.
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