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Differences in PrPSc accumulation or PrPC expression were assessed by unpaired t test by calculation of two-tailed P values.
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DIVA-GIS allows for model testing by calculation of the Area Under the Curve (AUC), referring to the Receiver Operation Characteristic (ROC) curve by using a subset of data (commonly 25 30%) as test points and the remaining ones as training points [45], [50].
Associations between categorical variables were tested by calculation of the X2 test.
Correlation between ORβ protein expression and tumour characteristics was tested by calculation of the Spearman coefficient.
Correlation between ORβ protein expression (IHC-score) and tumour characteristics was tested by calculation of the Spearman coefficient r.
Linear correlations between T cell diversity and patient age were tested by calculation of the Pearson's correlation coefficient.
The reliability of the responses to the questionnaires was tested by calculation of Cronbach's α where a value of >0.70 was considered reliable [ 62].
The effect of crystallite size distribution was tested by calculation of the intensities with different size crystallites and then combining; however, the broad conclusions are the same.
The framework status of the map was tested by calculation of likelihood of maps produced after all local permutations in a slipping window of 6 markers, and by global local inversions.
Resting-state EEG band power and coherence values were compared across all five groups (HC and 4 migraine phase groups) by the Wilcoxon rank-sum test, followed by calculation of the false discovery rate (FDR) for multiple comparisons.
The noise synthesis was extensively validated with a number of jury tests and by calculation of sound quality metrics.
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