The features of this test are that it is simple to conduct and requires minimal equipment: a bench/platform and an online computer program.
The alternative hypotheses of this test are that successes are spatially clustered or they are more evenly spaced than by chance.
The advantages of this test are that it is easy to implement and that there are statistical techniques that control for the fact that we are testing multiple tests at the same time.
The major limitations of the well-established troponin test are that it is dependent on time-relevant protein release kinetics and the fact that, by definition, patients with unstable angina cannot be diagnosed by troponin.
The two main differences between the collapsing method and the union test are that the former assumes that minor allele frequencies are low, i.e., ≤ 0.05, and that all markers are independent, i.e., there is no linkage disequilibrium (r2 = 0) [ 3].
The usual reasons cited for use of the score test are that it is the locally most powerful test [e.g. (Chen et al., 2013; Wu et al., 2011)] and that it is fast to compute because the parameters of the alternative model need not be estimated this computation is usually the most expensive one.
