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The tertiary endpoint was to evaluate, within the treatment group, if there is any difference in NT according to the type of progesterone administered, route of administration, and dose regimen.
A tertiary endpoint was the difference in overnight urinary albumin excretion (UAE) from baseline to 16 weeks.
Risk of relapse, risk of disability progression and the number of new or newly-enlarging T2 lesions (secondary endpoints), along with gadolinium-enhancing (Gd+) lesions (tertiary endpoint) were also reduced, when compared with placebo [ 4].
The Average Total Daily Dose of Morphine (morphine equivalent) used during Days 1 to 3 was a co-primary endpoint and the average Total Daily Dose of Morphine (morphine equivalent) used during Days 4 to 7 was a tertiary endpoint for the study.
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Tertiary endpoints included an assessment of SAEs up to 19 months post Dose 1.
Tertiary endpoints included translational biomarkers.
Tertiary endpoints included comparative safety at 1 year between the abatacept and infliximab groups.
Tertiary endpoints were the individual adjudicated components (as listed above) and total mortality.
Duration of response, stable disease, and health-related quality of life were assessed as tertiary endpoints.
The primary analyses assessed the CV risk for all primary, secondary, and tertiary endpoints associated with linagliptin versus total comparators.
Tertiary endpoints First occurrence of hospitalisation or death for upper gastrointestinal bleeding, perforation or obstruction not due to ulcers.
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