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Loops and tertiary architecture serve as mounting dovetails or wedges to eliminate external linking dowels.
Conversely, most single point mutations throughout key conserved features in peripheral tertiary architecture supporting the SAM binding pocket have relatively little impact on riboswitch activity.
Several defined suites of non-Watson Crick base pairs assemble inon-Watson Crickthat form recurrent, rather regular, baseding blocks of the tertiary architecture of folded RNAs.
Although the two proteins possess a similar tertiary architecture, yeast cyt c displays lower stability and, contrary to the equine protein, it does not bind ATP and lacks pro-apoptotic activity.
Recent structural studies have revealed that riboswitches, which bind a variety of small molecule metabolites, including purine bases, S-adenosylmethionine, amino acids and cofactors, can contain sophisticated tertiary architecture that enables their function, akin to tRNA and rRNA.
A combination of genetic, biochemical, and biophysical techniques demonstrate that Mg2+ induces a compacted tertiary architecture for M-box RNAs that regulates the accessibility of nucleotides involved in genetic control.
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RNAs adopt specific, stable tertiary architectures to perform their activities.
These results indicate that the EXXR motif is not required in all CYP tertiary architectures and only a single cysteine residue, which coordinates as the fifth thiolate ligand to the P450 haem iron, is invariant in all CYPs structures.
These experimental results clearly indicated that sorbitol, sucrose, and trehalose at a concentration of 0.75 M improved the refolding yields of GdnHCl-denatured BlTreA, probably due to the fact that these sugars favored the formation of tertiary architectures.
Recently, proteins with regular, repetitive tertiary structures have been identified that sidestep limitations imposed by globular protein architecture.
After nearly a century of investigations, similarly to other classes of macromolecular compounds, in the case of polyethyleneglycols (PEGn) and their derivatives (glyme, oligoglyme, PEGylated compounds), respectively, it can also be argued that besides a primary structure there is a secondary (conformational) and a tertiary (micellar macromolecular architectures) structure.
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