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But it has prompted questions in Seoul and Washington about what more might need to happen in terms of escalation to prompt a tougher response from either the South Koreans or even the US.
"Iraq is polarizing and polarized, and it's going to have a knock-on effect in terms of escalation elsewhere," said Hayder al-Khoei, an Iraq analyst at the London-based think tank Chatham House.
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Regan said the legal advice "should have been much more dramatic in terms of its escalation", prompting what appeared to be a frustrated response from Hayne.
"We seem to have missed the boat in terms of the escalation of T20 around the globe," he told BBC Radio Solent.
As postoperative administration of RT has some general disadvantages, neoadjuvant approaches could offer benefits in terms of dose escalation, target coverage and reduction of toxicity, especially if highly conformal techniques like intensity-modulated radiation therapy (IMRT) are considered.
The main perceived advantages of the standard design are threefold; its simplicity, its conservativeness in terms of cautious escalation and its ability to provide a reliable recommendation by using few patients.
As postoperative administration of radiation therapy has some general disadvantages, neoadjuvant and intraoperative approaches theoretically offer benefits in terms of dose escalation, reduction of toxicity and patients comfort especially if hypofractionated regimens with highly conformal techniques like intensity-modulated radiation therapy are considered.
Techniques such as three-dimensional conformal RT, intensity-modulated RT and image-guided RT offer the prospect of significant benefits, both in terms of dose escalation within the tumour and dose sparing in normal organs (Bhide and Nutting, 2010; Staffurth, 2010).
The goal of this trial was to assess the application of a de-escalation strategy and the impact in terms of re-escalation, recurrent infection and to identify variables associated with de-escalation.
We particularly analyzed the clinical impact of this attitude in terms of re-escalation, recurrent infection and mortality and identified bio-clinical variables associated with de-escalation.
We had full support in terms of managing escalations and execution coming off the separation.
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