Through randomized clinical studies, the effect of more liberal or restrictive triggers on long-term outcome can be studied, as well as the combination with a low (10 ml/kg) or high (20 ml/kg) transfusion volume.
Unlike laboratory experiments, which are usually restricted to short-term studies, natural sites offer the opportunity to predict OA effects in long-term adapted systems that can be studied in their entirety without the need for experimental manipulation (Hall-Spencer et al., 2008).
A shortcoming of the present assay, however, is the transient expression of the constructs and, therefore, only short-term responses of promoters can be studied.
For the first time, long-term IGF-1 treatment can be studied in children to determine if it enhances growth and this is a critical step in offering a therapy (much demanded by patients) for growth retardation in children with Crohn's disease.
Clathrin is a long-lived protein and thus, with clathrin knockdowns only long-term consequences of clathrin depletion can be studied.
A crucial advantage is that the effect of a drug molecule can be studied in terms of the cumulative systemic effects it introduces in the parasite, rather than just in terms of how it interacts with a specific protein or enzyme in isolation.
By analyzing the transition matrix, both the "short term" transient behavior and the "long term" limiting behavior of the model can be studied, thus putting the matrix at the center of attention for the biological interpretation of the results.
Thus, the natural reduction of eukaryotic cytoplasms can be studied in terms of evolution and functionality, giving additionally advices for the design of synthetic minimized compartments.
The complex behavior of externally stimulated integrate and fire oscillators has motivated the study of simplified models whose dynamics are determined by iterations of 'firing circle maps' that can be studied in terms of Poincaré's rotation theory [Chaos 1 (1991) 20; Chaos 1 (1991) 13; SIAM J. Appl. Math. 41 (3) (1981) 503].
