Sentence examples for termination of trials from inspiring English sources

These findings also support the recommendation in the Good Participatory Practice guidelines that prior to trial implementation, research teams need to develop plans for early termination of trials in consultation with relevant stakeholders [27].

This difference seemed to be associated with REC comments on clauses in clinical trial agreements for industry-sponsored trials, in particular regarding the publication of results and premature termination of trials.

Patients and control participants will follow the same study plan unless stated otherwise; an initial screening visit will be followed by an intervention period of 12 weeks and a follow-up visit in the week after termination of trial medication.

Considering the futility and potential harm confirmed by our findings and the early termination of two trials [ 4, 6], larger-scale trials in the same setting are not encouraged.

Discussion should be started on the inclusion of this minimal set of parameters in design/protocol papers and trial registries[ 154, 155] Reporting of DMC activities, interim analysis results and early termination of pediatric trials is incomplete and heterogeneous.

Early termination of clinical trials due to low recruitment represents an understudied challenge for clinical research.

Conditional power was not determined concurrently with the HRs during the monitoring of ACTIVE-W; however, the members of the DSMB now believe that such calculations should be considered as useful adjuncts to the calculation of HRs and could lead to earlier termination of noninferiority trials whose interim results suggest futility, without the need for convincing proof of harm.

While the corrections proposed for multiple sequential analyses may control for type 1 error they cannot prevent associated changes in the magnitude of treatment effect caused by early termination of small trials.

This led to premature termination of these trials and early disclosure of their results.

Adverse events with Dacogen and Evoltra were severe enough to warrant premature termination of clinical trials.

After termination of the trials, the treated would continue to accrue survival gain as long as there was a difference in cumulative mortality between the treatment arms.