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Termination of studies at the earliest possible point will minimise adverse effects on the animal.
Student numbers varied from one year to the next, due, for example, to termination of studies, withdrawal for health reasons, etc.
In addition to conducting studies that did not use placebo controls, other compromises included the use of surrogate endpoints, such as reduced CD4 counts, and early termination of studies based on preliminary data [ 56, 57].
Similar(57)
In both budesonide groups, FEV1 deteriorated significantly (P<0·01 and P<0·02, respectively) after termination of study medication and reached pretreatment values during the first month.
The standard necropsies procedures were carried out at the termination of study to collect the required tissues and blood sample for various analyses from mice of both sexes, as the study does not involve any gender specific parameters.
The most common reason for termination of study treatment was radiologically confirmed disease progression.
Among those, 40 patients were dead and 57 patients were alive until the termination of study.
Early termination of study in response to safety issues will be addressed via the DMC.
Mean weight of mice at initiation of study and termination of study did not differ significantly between the groups.
4. Students failing communication are referred to a committee, e.g. Academic Progress Board, who consider mitigation and can sanction termination of study.
All females had a urine pregnancy test performed at screening and at week 8 or at termination of study participation.
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