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Myo1c also regulates the termination of processive runs.
It would be straightforward to quantify termination of processive synthesis at each nucleotide position as synthesis proceeds, and map this pattern against the structural features that are hypothesized to be important for switching.
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Many polysaccharide hydrolases are capable of processive action, where they perform repeated attacks without dissociating from the substrate molecule.
Here we show that these functionalities can be uncoupled in chimera of processive and non-processive kinesins.
To locate these parts, we generated chimeric motors containing elements of processive NcKin1 and non-processive NcKin3.
This difference could play a role in governing the different rates of processive capping by various formin proteins.
However, Kinesin-1's neck domain can restore the characteristic inter-head coupling of processive kinesins in NcKin3.
Apparently, the wildtype neck of processive kinesins minimizes the diffusive search for the next microtubule-binding site.
This is also consistent with the enzyme encountering a loss of processive momentum due to the initially resistant guanine tract.
An important requisite of processive repeat synthesis is that telomerase remains bound to the telomere during the entire reaction cycle.
Most Endoglucanases on the other hand are non-processive; however a new class of processive endoglucanases has been identified in bacteria [ 15].
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