Unlike its analog cytosine arabinoside, which causes immediate termination of DNA polymerization, gemcitabine allows limited nucleotide polymerization by a process termed masked chain termination, which prevents exonucleases from excising the aberrant gemcitabine nucleotide [4], [5].
This was carried out over a time scale of 3 h up to 48 h polymerization time, enabling the efficient and repeatable termination of the polymerization reactions.
The depression of the rate of termination of the polymerization by the micelles was deduced to be responsible for the increased rate of copolymerization with AIBA.
Our technique established the conditions for mild termination of DNA polymerization with two Ara-C molecules.
The microfeature amplitude was tuned by shuttering UV radiation at specific times, which thereby prevented further initiation events and resulted in the rapid termination of the polymerization.
(B ) The catalytic cycle of Pol α consists of specific recognition of the templated RNA primer, rapid and limited primer extension with dNTPs and termination of synthesis induced by polymerization of B-form DNA.
The addition of a small amount of a Cu II Cl2/ligand complex along with the general benefits of high pressure of enhancing propagation and suppressing termination brought about an excellent control of polymerization even with an extremely low concentration of ATRP initiator.
For example, as indicated, the iron is necessary to decompose the hydrogen peroxide into the peroxy radicals that initiate the reaction while also participating to facilitate termination of the radicals during the polymerization.
