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On termination of phase 2, the percentage degradation of isoFA + 7EO was still increasing, indicating that a plateau would have been reached given enough time.
Both ethical and practical considerations often require early termination of phase II trials if early results clearly indicate that the new regimen is not active or worthy of further investigation.
We investigate the methods proposed by Conaway Petroni and Bryant Day allowing early termination of phase II clinical trials and based on joint evaluation of treatment efficacy and safety.
No effect of treatment on disability progression was seen in MAESTRO-01, leading to the termination of phase III trials MAESTRO-02 and MAESTRO-03.
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Data were realigned to termination of phase-locking events (i.e. phase-locking cessation).
A pulsatory cool climatic phase towards the termination of this phase, around 350 years ago (1650 AD), is evidenced by a sharp decline in the broad-leaved forests, which likely reflects the impact of a Little Ice Age event.
At the termination of each phase of 120 days, a metabolism trial of 6 days duration was conducted.
However, the combination of ipilimumab+BRAF inhibitor vemurafenib produced significant hepatotoxicity, requiring termination of a phase I trial.
Severe musculoskeletal, neurological, and ocular toxicities lead to the termination of a phase I study involving 13 patients with metastatic melanoma, breast or colon cancers [ 28].
Unfortunately, the lead Lilly molecule, LY2886721, produced hepatic adverse effects in AD patients (13 June 2013, Lilly press release) which forced termination of the phase II study.
At the behavioural level, a decrease of prolactin triggers the termination of aquatic phase and migration toward terrestrial habitat while at a morphological level the decrease of prolactin induces the decline of tail crest [ 63, 64, 73, 74].
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