The modifications encoded by the WAS donor template should cause premature termination of transcription due to the insertion of a polyadenylation site downstream of the neomycin-resistance gene (supplementary material Fig. S2).
The c.1954dupA (BIC 2080insA) mutation is a frame-shift causing insertion, resulting in termination of transcription at codon 672 and has been reported as a Pakistani founder mutation (Liede et al, 2002).
β-hydrogen transfer to metal, β-hydrogen transfer to monomer and hydrogenolysis were studied for 27 hafnocenes, initiating the chain termination reactions after insertion of the second ethene monomer.
Carbone et al. [ 49] have demonstrated for the first time that high rates of gross chromosome rearrangements can be a direct result of premature termination of transcripts of chromosome segregation genes due to insertion of these composite elements.
Also, peritoneal biopsies will be performed on occasion of intraabdominal sugery or laparoscopy prior to start and after termination of the study (usually at time of catheter insertion and renal transplantation).
Artificial termination of read-through transcription from the E1a promoter by insertion of ectopic transcription termination sequences (GGT: globin gene termination sequence) dramatically reduces early E1b gene expression in cis [20] [22].
Women infected with chlamydia or gonorrhoea are at increased risk of developing pelvic inflammatory disease following insertion of an intrauterine device or termination of pregnancy, 12 13 and would benefit from a rapid diagnosis.
The therapeutic effect of intranasal evaporative cooling was not diminished by the shallow insertion of catheter, nor impacted by premature termination of the treatment.
Since the retrovirus contains a polyadenylation signal within the R region of the LTR and a cryptic polyadenylation signal in the antisense orientation intragenic retroviral insertions in both orientations can cause premature termination of gene transcription.
Intragenic insertions may also cause gene inactivation, either through premature termination of transcription or by disrupting gene splicing (see [164]).
Also, several of the multi-transmembrane gene models appeared to be pseudogenes with various defects, including the insertion of stop codons and frame-shifting indels leading to premature termination of the coding region.
