Only five PCGs terminate with the complete termination codon TAA (atp8, atp6, cox3, nad4L and nad6).
Mutation of the termination codon resulted in production of a C-terminal elongated protein.
This terminator element was placed downstream from the transgene termination codon.
This deletion causes a frameshift resulting in the introduction of a termination codon in exon 679.
van Hoof, A., Frischmeyer, P.A., Dietz, H.C. & Parker, R. Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.
All the PCGs employ a complete translation termination codon either TAA or TAG except COII.
A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay.
Lykke-Andersen, J., Shu, M. D. & Steitz, J. A. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
van Hoof, A., Frischmeyer, P. A., Dietz, H. C. & Parker, R. Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.
A −1 PRF event on the CCR5 mRNA directs translating ribosomes to a premature termination codon, destabilizing it through the nonsense-mediated mRNA decay pathway.
A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner.
