Your English writing platform
Discover LudwigExact(1)
However, there is very little to be made to this extraneous threat to long-term trials, besides reconsiderations of the norms used in terminating trials.
Similar(59)
In particular, equipoise provides flawed ethical guidance for placebo-controlled trials and for decisions to terminate trials early based on interim data relating to benefit.
We terminated trials either after food retrieval, if five minutes had elapsed, or if the subject left the testing room for longer than 1 minute.
Three out of the five terminated trials were neonatal RCTs.
No relevant completed or terminated trials were registered.
Then, ongoing and terminated trials were removed based on their status and/or trial reports.
DMCs and interim analysis were mentioned in 21/32 (66%) and 22/32 (69%) of early terminated trials, respectively.
The frequency of reported early terminated trials in this sample was 21% (14/68) in general journals and 43% (18/42) in pediatric journals.
In summary, compared with the Simon optimal two-stage designs, our proposed BHT-A design can terminate trials of unpromising doses early, by utilizing a continuous monitoring rule and nonlocal alternative prior distributions in the hypothesis tests.
This prematurely terminated trial failed to show the anticipated increase in OS with MA over placebo, and patients on placebo generally had better outcomes in terms of QOL.
In a recently published, prematurely terminated trial, the use of HIV-entry inhibitor cellulose sulphate did not prevent, but might have increased the risk of HIV transmission (van Damme et al., 2008).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com