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We performed a binary outcome simulation study of a response adaptive randomized three-arm clinical trial with treatment arms A, B, and A&B that allowed for dropping an inferior treatment arm and terminating the trial early for superiority during any of 4 interim analyses.
Patients will be informed that terminating the trial will have no implications for future treatment.
Any decision on suspending or terminating the trial will be based on an evaluation of SAE reporting and monitoring visits.
The two-stage model was chosen with the purpose of terminating the trial if a minimum of four objective responses was not obtained out of the 19 patients.
In February 2010, the IDMC recommended terminating the trial because the recruitment rate was not compatible with a timely completion of the phase III trial.
The reasons for terminating the trial will be safety or poor study performance (e.g. slow accrual, high losses to follow-up and poor quality control).
Similar(53)
Selection of the incorrect stimulus terminated the trial.
It was petitioner, not the prosecutor, who sought to terminate the trial prior to verdict.
The full additivity model had slightly higher gains, but too frequently terminated the trial at the first interim look.
Increasingly, ill health among the accused, who are all over 80, threatens to terminate the trial completely.
Incorrect responses, namely the nose-pokes in right hopper after short signal or nose-pokes in left hopper after long signal, terminated the trial without pellet delivery.
More suggestions(16)
exiting the trial
canceling the trial
interrupting the trial
condemning the trial
ending the trial
completing the trial
separating the trial
finalising the trial
stopping the trial
dismissing the trial
disrupting the trial
discontinuing the trial
terminate the trial
aborting the trial
complete the trial
completed the trial
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com